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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
OPRM1
All Species:
17.27
Human Site:
S216
Identified Species:
47.5
UniProt:
P35372
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35372
NP_000905.3
400
44779
S216
T
T
K
Y
R
Q
G
S
I
D
C
T
L
T
F
Chimpanzee
Pan troglodytes
Q5IS39
401
44883
S217
T
T
K
Y
R
H
G
S
I
D
C
T
L
T
F
Rhesus Macaque
Macaca mulatta
Q9MYW9
400
44791
S216
T
T
K
Y
R
Q
G
S
I
D
C
T
L
T
F
Dog
Lupus familis
XP_541158
401
44921
S217
T
T
K
Y
R
H
G
S
I
D
C
T
L
T
F
Cat
Felis silvestris
Mouse
Mus musculus
P42866
398
44402
D216
K
Y
R
Q
G
S
I
D
C
T
L
T
F
S
H
Rat
Rattus norvegicus
P33535
398
44475
D216
K
Y
R
Q
G
S
I
D
C
T
L
T
F
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510524
312
35765
S139
T
T
K
Y
R
N
G
S
I
D
C
T
L
T
F
Chicken
Gallus gallus
XP_427506
366
40984
V193
T
K
T
K
D
G
T
V
L
C
T
L
Q
F
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_571782
384
43137
I211
S
D
L
H
S
N
G
I
I
D
C
T
L
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
98
96
N.A.
94
94
N.A.
73
62
N.A.
72.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99
99
97.5
N.A.
96.2
96.5
N.A.
75
71.7
N.A.
79
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
93.3
N.A.
6.6
6.6
N.A.
93.3
6.6
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
100
93.3
N.A.
20
20
N.A.
93.3
13.3
N.A.
60
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
23
12
67
0
0
0
0
% C
% Asp:
0
12
0
0
12
0
0
23
0
67
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
23
12
67
% F
% Gly:
0
0
0
0
23
12
67
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
12
0
23
0
0
0
0
0
0
0
0
23
% H
% Ile:
0
0
0
0
0
0
23
12
67
0
0
0
0
0
0
% I
% Lys:
23
12
56
12
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
12
0
0
0
0
0
12
0
23
12
67
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
23
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% P
% Gln:
0
0
0
23
0
23
0
0
0
0
0
0
12
0
0
% Q
% Arg:
0
0
23
0
56
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
12
0
0
0
12
23
0
56
0
0
0
0
0
23
0
% S
% Thr:
67
56
12
0
0
0
12
0
0
23
12
89
0
56
0
% T
% Val:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
23
0
56
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _